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KMID : 0361019960390060941
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 6 p.941 ~ p.945
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Role of Interleukin 6 in the Etiopathogenesis of Otitis Media with Effusion Using Immune Radiometric Assay
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Abstract
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It has been suggested that the activated local immune system is present in the middle ear and the effusion may be due to a local immune reaction in the middle ear. Several components of the immune response have been identified in effusions from
patients
with otitis media with effusion(OME). Interleukin 6(IL-6) is a cytokine with pleiotropic activities such as terminal differentiation in B cell, activation of T cells and support of multipotential colony formation by hematopoietic stem cells. We
measured
the levels of IL-6 in middle ear effusions using immune radiometric assay that is more sensitive and specific than enzyme linked immunosorbent assay or radioimmunoassay.
The levels of IL-6 in mucoid effusions were significantly higher than those in serous effusions(p<0.05). IL-6 was observed at the lowest levels in effusion of patients over than 11 years of age(p<0.01). The results suggest that IL-6 may play a
important
role as inflammatory mediator in the chronically persistent stage of OME in children. (Korean J Otolaryngo1 39 : 6, 1996)
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KEYWORD
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